La Plata was just a crossroads until the arrival of the railroad in 1869. The LaPlat train station now houses the Charles County Historical Society with an authentic red caboose on adjacent tracks.
The African-American Heritage House Museum in La Plata contains various artifacts that were used during the time of slavery. It depicts the life and history of African-Americans from 1658 to present.
Port Tobacco Parish was established in 1692 and was supported by a tobacco poll tax until 1776. In 1904 the church was dismantled and moved to its present site by oxcart that carried the numbered stones to La Plata - only to be destroyed by fire one year later. The present Church has an outstanding stained-glass collection and a Parish House that was added in 1903.